Drug interactions
Dalteparin + Meloxicam
Severity: Major
Dalteparin and Meloxicam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meloxicam adds to the bleeding risk of dalteparin through antiplatelet effects and gastrointestinal mucosal injury. Serious bleeding can occur.
What this interaction means in plain words
Dalteparin and Meloxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dalteparin belongs to Cardiovascular; Meloxicam belongs to Musculoskeletal.
Why it happens
Additive impairment of hemostasis from anticoagulation and NSAID platelet inhibition.
What to do
Avoid the combination where possible and use acetaminophen for analgesia. If both are needed, monitor for bleeding signs and hemoglobin.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Dalteparin with Meloxicam?
MediHelp rates the interaction as major. Dalteparin and Meloxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Meloxicam adds to the bleeding risk of dalteparin through antiplatelet effects and gastrointestinal mucosal injury. Serious bleeding can occur.
How serious is the interaction between Dalteparin and Meloxicam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use acetaminophen for analgesia. If both are needed, monitor for bleeding signs and hemoglobin.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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