Drug interactions
Dalteparin + Spironolactone
Severity: Moderate
Dalteparin and Spironolactone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparins, including low molecular weight heparins, can suppress aldosterone synthesis and cause hyperkalemia, which may add to the effect of spironolactone. The risk rises with renal impairment, diabetes and prolonged use.
What this interaction means in plain words
Dalteparin and Spironolactone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dalteparin belongs to Cardiovascular; Spironolactone belongs to Cardiovascular.
Why it happens
Heparin-induced inhibition of adrenal aldosterone synthesis adds to mineralocorticoid receptor blockade by spironolactone.
What to do
Check serum potassium at baseline and periodically during prolonged dalteparin use, particularly in patients with renal impairment. Adjust spironolactone if hyperkalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Dalteparin with Spironolactone?
MediHelp rates the interaction as moderate. Dalteparin and Spironolactone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparins, including low molecular weight heparins, can suppress aldosterone synthesis and cause hyperkalemia, which may add to the effect of spironolactone. The risk rises with renal impairment, diabetes and prolonged use.
How serious is the interaction between Dalteparin and Spironolactone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium at baseline and periodically during prolonged dalteparin use, particularly in patients with renal impairment. Adjust spironolactone if hyperkalemia develops.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
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