Drug interactions
Dalteparin + Triamterene
Severity: Moderate
Dalteparin and Triamterene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Low molecular weight heparins can suppress aldosterone synthesis and cause hyperkalemia, particularly with prolonged use or renal impairment. Combined with triamterene, this risk is increased.
What this interaction means in plain words
Dalteparin and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dalteparin belongs to Cardiovascular; Triamterene belongs to Cardiovascular.
Why it happens
Heparins inhibit adrenal aldosterone production, adding to the potassium-retaining action of triamterene.
What to do
Monitor serum potassium and renal function, especially if dalteparin is given for more than a few days. Consider holding triamterene if potassium becomes elevated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Dalteparin with Triamterene?
MediHelp rates the interaction as moderate. Dalteparin and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Low molecular weight heparins can suppress aldosterone synthesis and cause hyperkalemia, particularly with prolonged use or renal impairment. Combined with triamterene, this risk is increased.
How serious is the interaction between Dalteparin and Triamterene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function, especially if dalteparin is given for more than a few days. Consider holding triamterene if potassium becomes elevated.
What other medicines interact with Triamterene?
MediHelp also lists interactions of Triamterene with, for example, Amiloride, Eplerenone, Potassium citrate / citric acid. The full list is on the Triamterene page.
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