Drug interactions
Dalteparin + Valsartan
Severity: Moderate
Dalteparin and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparins, including low molecular weight heparins, suppress adrenal aldosterone secretion and can cause hyperkalemia. With valsartan, which also reduces aldosterone effect, the risk of elevated potassium increases, especially in renal impairment or diabetes.
What this interaction means in plain words
Dalteparin and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dalteparin belongs to Cardiovascular; Valsartan belongs to Cardiovascular.
Why it happens
Additive suppression of the renin-angiotensin-aldosterone axis leads to potassium retention.
What to do
Monitor serum potassium and renal function, particularly with prolonged dalteparin therapy or in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Dalteparin with Valsartan?
MediHelp rates the interaction as moderate. Dalteparin and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparins, including low molecular weight heparins, suppress adrenal aldosterone secretion and can cause hyperkalemia. With valsartan, which also reduces aldosterone effect, the risk of elevated potassium increases, especially in renal impairment or diabetes.
How serious is the interaction between Dalteparin and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function, particularly with prolonged dalteparin therapy or in high-risk patients.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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