Drug interactions
Danazol + Dantrolene
Severity: Minor
Danazol and Dantrolene: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a CYP3A4 inhibitor and could modestly raise dantrolene exposure. Danazol is itself hepatotoxic, so overlapping liver risk is a further concern.
What this interaction means in plain words
Danazol and Dantrolene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Danazol inhibits CYP3A4, which may reduce dantrolene metabolism; the clinical relevance is not well established.
What to do
Monitor liver function tests periodically and watch for increased weakness or drowsiness. Reduce dantrolene if adverse effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dantrolene
Frequently asked questions
Can I take Danazol with Dantrolene?
MediHelp rates the interaction as minor. Danazol and Dantrolene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol is a CYP3A4 inhibitor and could modestly raise dantrolene exposure. Danazol is itself hepatotoxic, so overlapping liver risk is a further concern.
How serious is the interaction between Danazol and Dantrolene?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests periodically and watch for increased weakness or drowsiness. Reduce dantrolene if adverse effects emerge.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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