Drug interactions
Danazol + Estradiol
Severity: Minor
Danazol and Estradiol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak CYP3A4 inhibitor and could slightly raise estradiol exposure. Danazol is also an androgenic agent that suppresses ovarian estrogen production and is often used for opposing purposes, so the combination is clinically counterproductive in many settings.
What this interaction means in plain words
Danazol and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 inhibition by danazol may reduce estradiol metabolism; the pharmacodynamic effects are opposing.
What to do
Review the therapeutic rationale for combining them and monitor for estrogenic adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Danazol with Estradiol?
MediHelp rates the interaction as minor. Danazol and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol is a weak CYP3A4 inhibitor and could slightly raise estradiol exposure. Danazol is also an androgenic agent that suppresses ovarian estrogen production and is often used for opposing purposes, so the combination is clinically counterproductive in many settings.
How serious is the interaction between Danazol and Estradiol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the therapeutic rationale for combining them and monitor for estrogenic adverse effects.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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