Drug interactions
Danazol + Glipizide
Severity: Minor
Danazol and Glipizide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol, an androgenic agent, can cause insulin resistance and altered glucose tolerance, so its effect on glipizide is unpredictable and usually toward reduced control. The interaction is documented mainly as a labeled caution rather than robust data.
What this interaction means in plain words
Danazol and Glipizide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Androgenic effects on insulin sensitivity and glucose metabolism; direction of effect with sulfonylureas is not firmly established.
What to do
Monitor blood glucose when danazol is started or stopped and adjust the glipizide dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide
Frequently asked questions
Can I take Danazol with Glipizide?
MediHelp rates the interaction as minor. Danazol and Glipizide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol, an androgenic agent, can cause insulin resistance and altered glucose tolerance, so its effect on glipizide is unpredictable and usually toward reduced control. The interaction is documented mainly as a labeled caution rather than robust data.
How serious is the interaction between Danazol and Glipizide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when danazol is started or stopped and adjust the glipizide dose as needed.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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