Drug interactions
Danazol + Insulin degludec-insulin aspart
Severity: Moderate
Danazol and Insulin degludec-insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol can induce insulin resistance and impair glucose tolerance, which may raise insulin requirements and worsen glycemic control in diabetic patients.
What this interaction means in plain words
Danazol and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Androgenic activity of danazol reduces insulin sensitivity, antagonizing insulin's effect.
What to do
Monitor glucose closely during danazol therapy and increase insulin doses as needed; reassess when danazol is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Frequently asked questions
Can I take Danazol with Insulin degludec-insulin aspart?
MediHelp rates the interaction as moderate. Danazol and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol can induce insulin resistance and impair glucose tolerance, which may raise insulin requirements and worsen glycemic control in diabetic patients.
How serious is the interaction between Danazol and Insulin degludec-insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose closely during danazol therapy and increase insulin doses as needed; reassess when danazol is stopped.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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