Drug interactions
Danazol + Methylprednisolone
Severity: Moderate
Danazol and Methylprednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol inhibits CYP3A4 and may raise methylprednisolone concentrations, increasing the risk of corticosteroid adverse effects such as fluid retention, hyperglycemia and adrenal suppression. Both agents can also cause fluid retention.
What this interaction means in plain words
Danazol and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Danazol inhibits CYP3A4-mediated metabolism of methylprednisolone, and both drugs have additive fluid-retaining effects.
What to do
Monitor for steroid excess, edema, blood pressure and glucose. Reduce the methylprednisolone dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Frequently asked questions
Can I take Danazol with Methylprednisolone?
MediHelp rates the interaction as moderate. Danazol and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol inhibits CYP3A4 and may raise methylprednisolone concentrations, increasing the risk of corticosteroid adverse effects such as fluid retention, hyperglycemia and adrenal suppression. Both agents can also cause fluid retention.
How serious is the interaction between Danazol and Methylprednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for steroid excess, edema, blood pressure and glucose. Reduce the methylprednisolone dose if adverse effects emerge.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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