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Drug interactions

Danazol + Mirtazapine

Severity: Minor

Danazol and Mirtazapine: minor interaction.

Last updated

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Danazol is a weak CYP3A4 inhibitor and may modestly increase mirtazapine concentrations. A clinically meaningful effect is uncommon.

What this interaction means in plain words

Danazol and Mirtazapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.

Evidence level: Low

Why it happens

Danazol weakly inhibits CYP3A4-mediated mirtazapine metabolism.

What to do

Monitor for increased sedation or dizziness and reduce the mirtazapine dose if these occur.

What to ask your pharmacist

  • Is there anything I should notice while taking both?
  • Do I need to tell my doctor at the next visit?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Frequently asked questions

Can I take Danazol with Mirtazapine?

MediHelp rates the interaction as minor. Danazol and Mirtazapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol is a weak CYP3A4 inhibitor and may modestly increase mirtazapine concentrations. A clinically meaningful effect is uncommon.

How serious is the interaction between Danazol and Mirtazapine?

MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation or dizziness and reduce the mirtazapine dose if these occur.

What other medicines interact with Mirtazapine?

MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.

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