Drug interactions
Danazol + Modafinil
Severity: Minor
Danazol and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak CYP3A4 inhibitor and could modestly raise modafinil concentrations. The clinical effect is likely small.
What this interaction means in plain words
Danazol and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Danazol inhibition of CYP3A4-mediated modafinil metabolism.
What to do
Monitor for modafinil adverse effects such as insomnia, anxiety and headache; reduce the dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Modafinil
Frequently asked questions
Can I take Danazol with Modafinil?
MediHelp rates the interaction as minor. Danazol and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol is a weak CYP3A4 inhibitor and could modestly raise modafinil concentrations. The clinical effect is likely small.
How serious is the interaction between Danazol and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for modafinil adverse effects such as insomnia, anxiety and headache; reduce the dose if they occur.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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