Drug interactions
Danazol + Nevirapine
Severity: Minor
Danazol and Nevirapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak CYP3A4 inhibitor and could modestly raise nevirapine concentrations. Because nevirapine has dose-related toxicity including rash and hepatotoxicity, an increase could matter, although the effect is likely small.
What this interaction means in plain words
Danazol and Nevirapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Danazol weakly inhibits CYP3A4, reducing the metabolism of nevirapine.
What to do
Monitor for rash and liver enzyme elevation when starting danazol in patients on nevirapine; no preemptive dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Danazol with Nevirapine?
MediHelp rates the interaction as minor. Danazol and Nevirapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol is a weak CYP3A4 inhibitor and could modestly raise nevirapine concentrations. Because nevirapine has dose-related toxicity including rash and hepatotoxicity, an increase could matter, although the effect is likely small.
How serious is the interaction between Danazol and Nevirapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for rash and liver enzyme elevation when starting danazol in patients on nevirapine; no preemptive dose change is needed.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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