Drug interactions
Danazol + Oxycodone
Severity: Moderate
Danazol and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a CYP3A4 inhibitor and may increase oxycodone exposure, raising the risk of excessive sedation and respiratory depression. The effect is predicted from the mechanism.
What this interaction means in plain words
Danazol and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated oxycodone metabolism by danazol.
What to do
Monitor for sedation and slowed breathing, and lower the oxycodone dose if signs of excess opioid effect appear. Reassess dosing when danazol is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Frequently asked questions
Can I take Danazol with Oxycodone?
MediHelp rates the interaction as moderate. Danazol and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a CYP3A4 inhibitor and may increase oxycodone exposure, raising the risk of excessive sedation and respiratory depression. The effect is predicted from the mechanism.
How serious is the interaction between Danazol and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and slowed breathing, and lower the oxycodone dose if signs of excess opioid effect appear. Reassess dosing when danazol is started or stopped.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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