Drug interactions
Danazol + Palbociclib
Severity: Minor
Danazol and Palbociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak CYP3A4 inhibitor and may slightly raise palbociclib exposure. The clinical significance is probably small but could add to neutropenia.
What this interaction means in plain words
Danazol and Palbociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Danazol weakly inhibits CYP3A4, reducing palbociclib metabolism.
What to do
No empirical dose change is needed; monitor blood counts as per routine palbociclib care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Palbociclib
Frequently asked questions
Can I take Danazol with Palbociclib?
MediHelp rates the interaction as minor. Danazol and Palbociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol is a weak CYP3A4 inhibitor and may slightly raise palbociclib exposure. The clinical significance is probably small but could add to neutropenia.
How serious is the interaction between Danazol and Palbociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor blood counts as per routine palbociclib care.
What other medicines interact with Palbociclib?
MediHelp also lists interactions of Palbociclib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Palbociclib page.
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