Drug interactions
Apalutamide + Palbociclib
Severity: Major
Apalutamide and Palbociclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may lower palbociclib concentrations and reduce efficacy. Strong CYP3A inducers reduce palbociclib exposure, and labeling advises avoiding them.
What this interaction means in plain words
Apalutamide and Palbociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Palbociclib belongs to Oncology.
Why it happens
CYP3A4 induction by apalutamide accelerates palbociclib metabolism.
What to do
Avoid concomitant use and choose a non-inducing alternative. If unavoidable, monitor for loss of efficacy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Palbociclib
Frequently asked questions
Can I take Apalutamide with Palbociclib?
MediHelp rates the interaction as major. Apalutamide and Palbociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide may lower palbociclib concentrations and reduce efficacy. Strong CYP3A inducers reduce palbociclib exposure, and labeling advises avoiding them.
How serious is the interaction between Apalutamide and Palbociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use and choose a non-inducing alternative. If unavoidable, monitor for loss of efficacy.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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