Drug interactions
Chloramphenicol + Palbociclib
Severity: Major
Chloramphenicol and Palbociclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palbociclib is cleared mainly via CYP3A4, so inhibition may increase exposure and neutropenia. Chloramphenicol itself causes bone marrow suppression, compounding the risk.
What this interaction means in plain words
Chloramphenicol and Palbociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Palbociclib belongs to Oncology.
Why it happens
Chloramphenicol inhibits CYP3A4 and adds myelosuppression.
What to do
Prefer an alternative antibiotic. If combined, monitor complete blood counts closely and reduce the palbociclib dose as for CYP3A inhibitors.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chloramphenicol
Other interactions of Palbociclib
Frequently asked questions
Can I take Chloramphenicol with Palbociclib?
MediHelp rates the interaction as major. Chloramphenicol and Palbociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Palbociclib is cleared mainly via CYP3A4, so inhibition may increase exposure and neutropenia. Chloramphenicol itself causes bone marrow suppression, compounding the risk.
How serious is the interaction between Chloramphenicol and Palbociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antibiotic. If combined, monitor complete blood counts closely and reduce the palbociclib dose as for CYP3A inhibitors.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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