Drug interactions
Atazanavir + Palbociclib
Severity: Major
Atazanavir and Palbociclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir is a potent CYP3A4 inhibitor and can substantially raise palbociclib exposure. This increases the risk of neutropenia and other dose-related toxicities of palbociclib.
What this interaction means in plain words
Atazanavir and Palbociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Palbociclib belongs to Oncology.
Why it happens
Strong inhibition of CYP3A4-mediated palbociclib metabolism reduces its clearance.
What to do
Avoid the combination where possible and choose an alternative antiretroviral. If unavoidable, reduce the palbociclib dose to 75 mg daily and monitor blood counts closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Palbociclib
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Palbociclib?
MediHelp rates the interaction as major. Atazanavir and Palbociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir is a potent CYP3A4 inhibitor and can substantially raise palbociclib exposure. This increases the risk of neutropenia and other dose-related toxicities of palbociclib.
How serious is the interaction between Atazanavir and Palbociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose an alternative antiretroviral. If unavoidable, reduce the palbociclib dose to 75 mg daily and monitor blood counts closely.
What other medicines interact with Palbociclib?
MediHelp also lists interactions of Palbociclib with, for example, Apalutamide, Carbamazepine, Ceritinib. The full list is on the Palbociclib page.
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