Drug interactions
Ceritinib + Palbociclib
Severity: Major
Ceritinib and Palbociclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib inhibits CYP3A4 and may raise palbociclib concentrations. Higher exposure may worsen myelosuppression, especially neutropenia.
What this interaction means in plain words
Ceritinib and Palbociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ceritinib belongs to Oncology; Palbociclib belongs to Oncology.
Why it happens
Ceritinib inhibits CYP3A4, reducing the metabolic clearance of palbociclib.
What to do
Avoid the combination if possible. If used together, monitor complete blood counts frequently and consider reducing the palbociclib dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Palbociclib
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Palbociclib?
MediHelp rates the interaction as major. Ceritinib and Palbociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ceritinib inhibits CYP3A4 and may raise palbociclib concentrations. Higher exposure may worsen myelosuppression, especially neutropenia.
How serious is the interaction between Ceritinib and Palbociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If used together, monitor complete blood counts frequently and consider reducing the palbociclib dose.
What other medicines interact with Palbociclib?
MediHelp also lists interactions of Palbociclib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Palbociclib page.
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