Drug interactions
Danazol + Ranolazine
Severity: Moderate
Danazol and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak to moderate CYP3A4 inhibitor and may increase ranolazine concentrations. Higher ranolazine exposure may increase dizziness, nausea and QT prolongation.
What this interaction means in plain words
Danazol and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Danazol inhibits CYP3A4-mediated metabolism of ranolazine.
What to do
Watch for dose-related adverse effects and QTc changes, and lower the ranolazine dose if they occur. Do not exceed the labeled maximum dose when a moderate CYP3A inhibitor is involved.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Danazol with Ranolazine?
MediHelp rates the interaction as moderate. Danazol and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a weak to moderate CYP3A4 inhibitor and may increase ranolazine concentrations. Higher ranolazine exposure may increase dizziness, nausea and QT prolongation.
How serious is the interaction between Danazol and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for dose-related adverse effects and QTc changes, and lower the ranolazine dose if they occur. Do not exceed the labeled maximum dose when a moderate CYP3A inhibitor is involved.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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