Drug interactions
Danazol + Ropivacaine
Severity: Minor
Danazol and Ropivacaine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a CYP3A4 inhibitor and could modestly raise ropivacaine concentrations. Because CYP1A2 is the main route for ropivacaine, the effect is expected to be small.
What this interaction means in plain words
Danazol and Ropivacaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Danazol inhibits CYP3A4, a secondary pathway of ropivacaine metabolism.
What to do
No dose change is generally needed; monitor for signs of local anesthetic toxicity during prolonged infusions.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ropivacaine
- Bupivacaine implant + Ropivacaine Major
- Bupivacaine liposome + Ropivacaine Major
- Amlodipine-benazepril + Ropivacaine Moderate
- Benazepril + Ropivacaine Moderate
- Captopril-hydrochlorothiazide + Ropivacaine Moderate
- Captopril + Ropivacaine Moderate
Frequently asked questions
Can I take Danazol with Ropivacaine?
MediHelp rates the interaction as minor. Danazol and Ropivacaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol is a CYP3A4 inhibitor and could modestly raise ropivacaine concentrations. Because CYP1A2 is the main route for ropivacaine, the effect is expected to be small.
How serious is the interaction between Danazol and Ropivacaine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor for signs of local anesthetic toxicity during prolonged infusions.
What other medicines interact with Ropivacaine?
MediHelp also lists interactions of Ropivacaine with, for example, Bupivacaine implant, Bupivacaine liposome, Amlodipine-benazepril. The full list is on the Ropivacaine page.
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