Drug interactions
Danazol + Ruxolitinib
Severity: Minor
Danazol and Ruxolitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak CYP3A4 inhibitor and may slightly raise ruxolitinib levels. Danazol is sometimes used for myelofibrosis anemia, so the combination occurs in practice, and added cytopenia risk is modest.
What this interaction means in plain words
Danazol and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 inhibition by danazol reduces ruxolitinib clearance.
What to do
No routine dose change; monitor blood counts and adjust ruxolitinib if cytopenias occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ruxolitinib
Frequently asked questions
Can I take Danazol with Ruxolitinib?
MediHelp rates the interaction as minor. Danazol and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol is a weak CYP3A4 inhibitor and may slightly raise ruxolitinib levels. Danazol is sometimes used for myelofibrosis anemia, so the combination occurs in practice, and added cytopenia risk is modest.
How serious is the interaction between Danazol and Ruxolitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change; monitor blood counts and adjust ruxolitinib if cytopenias occur.
What other medicines interact with Ruxolitinib?
MediHelp also lists interactions of Ruxolitinib with, for example, Atazanavir, Ceritinib, Chloramphenicol. The full list is on the Ruxolitinib page.
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