Drug interactions
Danazol + Trazodone
Severity: Moderate
Danazol and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak to moderate CYP3A4 inhibitor, and trazodone is cleared mainly by CYP3A4. Exposure to trazodone may rise, increasing sedation, dizziness, orthostatic hypotension and potentially QT-related risk.
What this interaction means in plain words
Danazol and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated trazodone metabolism by danazol.
What to do
Start trazodone at a low dose and titrate according to tolerability. Monitor for excessive sedation, hypotension and arrhythmia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Danazol with Trazodone?
MediHelp rates the interaction as moderate. Danazol and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a weak to moderate CYP3A4 inhibitor, and trazodone is cleared mainly by CYP3A4. Exposure to trazodone may rise, increasing sedation, dizziness, orthostatic hypotension and potentially QT-related risk.
How serious is the interaction between Danazol and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start trazodone at a low dose and titrate according to tolerability. Monitor for excessive sedation, hypotension and arrhythmia symptoms.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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