Drug interactions
Danazol + Trimipramine
Severity: Minor
Danazol and Trimipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol inhibits CYP3A4 and could raise trimipramine concentrations, which could increase sedation, anticholinergic effects, and cardiac conduction effects. The clinical evidence is limited, since trimipramine is cleared by several enzymes.
What this interaction means in plain words
Danazol and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Danazol inhibition of CYP3A4 may reduce trimipramine metabolism.
What to do
Monitor for signs of tricyclic excess such as sedation, dry mouth, and palpitations. Reduce the trimipramine dose if these occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Danazol with Trimipramine?
MediHelp rates the interaction as minor. Danazol and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol inhibits CYP3A4 and could raise trimipramine concentrations, which could increase sedation, anticholinergic effects, and cardiac conduction effects. The clinical evidence is limited, since trimipramine is cleared by several enzymes.
How serious is the interaction between Danazol and Trimipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of tricyclic excess such as sedation, dry mouth, and palpitations. Reduce the trimipramine dose if these occur.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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