Drug interactions
Danazol + Vortioxetine
Severity: Minor
Danazol and Vortioxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak to moderate CYP3A4 inhibitor, but vortioxetine is cleared mainly via CYP2D6, so any rise in exposure is likely small.
What this interaction means in plain words
Danazol and Vortioxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 inhibition by danazol reduces a minor vortioxetine clearance pathway.
What to do
No dose adjustment is expected. Monitor for increased adverse effects such as nausea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Danazol with Vortioxetine?
MediHelp rates the interaction as minor. Danazol and Vortioxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol is a weak to moderate CYP3A4 inhibitor, but vortioxetine is cleared mainly via CYP2D6, so any rise in exposure is likely small.
How serious is the interaction between Danazol and Vortioxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is expected. Monitor for increased adverse effects such as nausea.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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