Drug interactions
Danazol + Zonisamide
Severity: Moderate
Danazol and Zonisamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol inhibits CYP3A4 and may raise zonisamide concentrations. This could increase dose-related adverse effects such as somnolence, dizziness and cognitive slowing.
What this interaction means in plain words
Danazol and Zonisamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by danazol decreases the metabolism of zonisamide.
What to do
Monitor for zonisamide toxicity when danazol is started and consider reducing the zonisamide dose. Recheck when danazol is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zonisamide
- Zonisamide + Zuranolone Major
- Acetazolamide + Zonisamide Moderate
- Amisulpride + Zonisamide Moderate
- Amobarbital + Zonisamide Moderate
- Apalutamide + Zonisamide Moderate
- Asenapine transdermal + Zonisamide Moderate
Frequently asked questions
Can I take Danazol with Zonisamide?
MediHelp rates the interaction as moderate. Danazol and Zonisamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol inhibits CYP3A4 and may raise zonisamide concentrations. This could increase dose-related adverse effects such as somnolence, dizziness and cognitive slowing.
How serious is the interaction between Danazol and Zonisamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for zonisamide toxicity when danazol is started and consider reducing the zonisamide dose. Recheck when danazol is stopped.
What other medicines interact with Zonisamide?
MediHelp also lists interactions of Zonisamide with, for example, Zuranolone, Acetazolamide, Amisulpride. The full list is on the Zonisamide page.
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