Drug interactions
Danicopan + Ethinyl estradiol-norgestimate
Severity: Moderate
Danicopan and Ethinyl estradiol-norgestimate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits BCRP and may increase exposure to BCRP substrates, which could include ethinyl estradiol. Higher estrogen exposure could increase estrogen-related adverse effects, though the clinical significance is not well defined.
What this interaction means in plain words
Danicopan and Ethinyl estradiol-norgestimate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Danicopan belongs to Miscellaneous; Ethinyl estradiol-norgestimate belongs to Endocrine.
Why it happens
Danicopan inhibits the BCRP efflux transporter, which may increase the absorption and systemic exposure of ethinyl estradiol.
What to do
Monitor for estrogenic adverse effects such as nausea, breast tenderness and hypertension. Consider a lower-estrogen product if effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Ethinyl estradiol-norgestimate?
MediHelp rates the interaction as moderate. Danicopan and Ethinyl estradiol-norgestimate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits BCRP and may increase exposure to BCRP substrates, which could include ethinyl estradiol. Higher estrogen exposure could increase estrogen-related adverse effects, though the clinical significance is not well defined.
How serious is the interaction between Danicopan and Ethinyl estradiol-norgestimate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogenic adverse effects such as nausea, breast tenderness and hypertension. Consider a lower-estrogen product if effects emerge.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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