Drug interactions
Danicopan + Glibenclamide
Severity: Moderate
Danicopan and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits the breast cancer resistance protein (BCRP) efflux transporter, which can raise systemic exposure to glyburide. Higher glyburide levels may strengthen its glucose-lowering effect and increase the risk of hypoglycemia.
What this interaction means in plain words
Danicopan and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Danicopan belongs to Miscellaneous; Glibenclamide belongs to Endocrine.
Why it happens
Danicopan inhibits BCRP-mediated efflux, which increases glyburide plasma concentrations.
What to do
Monitor blood glucose when danicopan is started or stopped and reduce the glyburide dose if hypoglycemia occurs. Teach patients to recognize hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Glibenclamide?
MediHelp rates the interaction as moderate. Danicopan and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits the breast cancer resistance protein (BCRP) efflux transporter, which can raise systemic exposure to glyburide. Higher glyburide levels may strengthen its glucose-lowering effect and increase the risk of hypoglycemia.
How serious is the interaction between Danicopan and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when danicopan is started or stopped and reduce the glyburide dose if hypoglycemia occurs. Teach patients to recognize hypoglycemia symptoms.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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