Drug interactions
Danicopan + Hydrocortisone
Severity: Minor
Danicopan and Hydrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-glycoprotein and can increase exposure to P-gp substrates such as hydrocortisone. The clinical effect is likely small but may be more notable at higher steroid doses.
What this interaction means in plain words
Danicopan and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Danicopan belongs to Miscellaneous; Hydrocortisone belongs to Endocrine.
Why it happens
Danicopan inhibits intestinal P-glycoprotein efflux, increasing hydrocortisone absorption and exposure.
What to do
Monitor for corticosteroid adverse effects such as hyperglycemia and fluid retention. Consider reducing the hydrocortisone dose if effects appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Hydrocortisone?
MediHelp rates the interaction as minor. Danicopan and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danicopan inhibits P-glycoprotein and can increase exposure to P-gp substrates such as hydrocortisone. The clinical effect is likely small but may be more notable at higher steroid doses.
How serious is the interaction between Danicopan and Hydrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid adverse effects such as hyperglycemia and fluid retention. Consider reducing the hydrocortisone dose if effects appear.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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