Drug interactions
Danicopan + Metformin-sitagliptin
Severity: Minor
Danicopan and Metformin-sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-glycoprotein and may increase sitagliptin exposure. The clinical effect is likely small given sitagliptin's wide therapeutic margin.
What this interaction means in plain words
Danicopan and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Danicopan belongs to Miscellaneous; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Inhibition of intestinal and renal P-glycoprotein efflux increases sitagliptin exposure.
What to do
No empiric dose change is required; monitor blood glucose and sitagliptin tolerability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-sitagliptin
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Metformin-sitagliptin?
MediHelp rates the interaction as minor. Danicopan and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danicopan inhibits P-glycoprotein and may increase sitagliptin exposure. The clinical effect is likely small given sitagliptin's wide therapeutic margin.
How serious is the interaction between Danicopan and Metformin-sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is required; monitor blood glucose and sitagliptin tolerability.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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