Drug interactions
Danicopan + Pitavastatin
Severity: Moderate
Danicopan and Pitavastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits BCRP and can increase plasma levels of BCRP substrates. Pitavastatin is a BCRP substrate, so higher statin exposure and a greater risk of myopathy are possible.
What this interaction means in plain words
Danicopan and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Danicopan belongs to Miscellaneous; Pitavastatin belongs to Cardiovascular.
Why it happens
Danicopan inhibits BCRP, which reduces efflux of pitavastatin and increases its exposure.
What to do
Use the lowest effective pitavastatin dose and monitor for muscle pain or weakness. Check CK if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pitavastatin
- Cyclosporine + Pitavastatin Contraindicated
- Cyclosporin + Pitavastatin Contraindicated
- Erythromycin base + Pitavastatin Major
- Erythromycin ethylsuccinate + Pitavastatin Major
- Erythromycin lactobionate + Pitavastatin Major
- Erythromycin stearate + Pitavastatin Major
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Pitavastatin?
MediHelp rates the interaction as moderate. Danicopan and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits BCRP and can increase plasma levels of BCRP substrates. Pitavastatin is a BCRP substrate, so higher statin exposure and a greater risk of myopathy are possible.
How serious is the interaction between Danicopan and Pitavastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective pitavastatin dose and monitor for muscle pain or weakness. Check CK if symptoms develop.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporine, Cyclosporin, Erythromycin base. The full list is on the Pitavastatin page.
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