Drug interactions
Danicopan + Tenofovir disoproxil
Severity: Moderate
Danicopan and Tenofovir disoproxil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-gp and BCRP and can increase exposure to substrates of these transporters. Tenofovir disoproxil absorption may rise, increasing the potential for adverse effects.
What this interaction means in plain words
Danicopan and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Danicopan inhibits intestinal P-gp and BCRP, increasing tenofovir absorption.
What to do
Monitor renal function and tenofovir-related toxicity during combined use. Consider tenofovir dose adjustment if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Tenofovir disoproxil?
MediHelp rates the interaction as moderate. Danicopan and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-gp and BCRP and can increase exposure to substrates of these transporters. Tenofovir disoproxil absorption may rise, increasing the potential for adverse effects.
How serious is the interaction between Danicopan and Tenofovir disoproxil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and tenofovir-related toxicity during combined use. Consider tenofovir dose adjustment if toxicity develops.
What other medicines interact with Danicopan?
MediHelp also lists interactions of Danicopan with, for example, Amiodarone, Apixaban, Atorvastatin. The full list is on the Danicopan page.
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