Drug interactions
Dantrolene + Difenoxin
Severity: Moderate
Dantrolene and Difenoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difenoxin is an opioid-derived antidiarrheal that can cause drowsiness and dizziness at therapeutic doses and more marked CNS depression with overuse. Dantrolene adds sedation and weakness, so the combination may increase impairment.
What this interaction means in plain words
Dantrolene and Difenoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Difenoxin belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression from opioid-related central effects and dantrolene sedation.
What to do
Use the lowest effective difenoxin dose and monitor for excessive sedation. Advise against driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Difenoxin
Frequently asked questions
Can I take Dantrolene with Difenoxin?
MediHelp rates the interaction as moderate. Dantrolene and Difenoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difenoxin is an opioid-derived antidiarrheal that can cause drowsiness and dizziness at therapeutic doses and more marked CNS depression with overuse. Dantrolene adds sedation and weakness, so the combination may increase impairment.
How serious is the interaction between Dantrolene and Difenoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective difenoxin dose and monitor for excessive sedation. Advise against driving until the response is known.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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