Drug interactions
Dantrolene + Droperidol
Severity: Moderate
Dantrolene and Droperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Droperidol is a sedating butyrophenone antipsychotic, and dantrolene adds drowsiness and muscle weakness. The combination can deepen sedation and impair alertness, particularly in perioperative settings.
What this interaction means in plain words
Dantrolene and Droperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from dopamine antagonism-related sedation and dantrolene effects.
What to do
Monitor sedation level and vital signs when combined and reduce doses if oversedation occurs. Consider the QT effects of droperidol independently.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Droperidol?
MediHelp rates the interaction as moderate. Dantrolene and Droperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Droperidol is a sedating butyrophenone antipsychotic, and dantrolene adds drowsiness and muscle weakness. The combination can deepen sedation and impair alertness, particularly in perioperative settings.
How serious is the interaction between Dantrolene and Droperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and vital signs when combined and reduce doses if oversedation occurs. Consider the QT effects of droperidol independently.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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