Drug interactions
Dantrolene + Encorafenib
Severity: Moderate
Dantrolene and Encorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dantrolene is metabolized in part by hepatic enzymes, and encorafenib has mixed inhibitory and inducing effects on CYP3A4. The net effect on dantrolene exposure is uncertain and could mean either increased toxicity or reduced effect.
What this interaction means in plain words
Dantrolene and Encorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Encorafenib belongs to Oncology.
Why it happens
Encorafenib both inhibits and induces CYP3A4, which may alter dantrolene metabolism unpredictably.
What to do
Monitor for loss of efficacy and for adverse effects including hepatotoxicity, sedation and weakness. Check liver function periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Encorafenib
Frequently asked questions
Can I take Dantrolene with Encorafenib?
MediHelp rates the interaction as moderate. Dantrolene and Encorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dantrolene is metabolized in part by hepatic enzymes, and encorafenib has mixed inhibitory and inducing effects on CYP3A4. The net effect on dantrolene exposure is uncertain and could mean either increased toxicity or reduced effect.
How serious is the interaction between Dantrolene and Encorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of efficacy and for adverse effects including hepatotoxicity, sedation and weakness. Check liver function periodically.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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