Drug interactions
Dantrolene + Esketamine
Severity: Moderate
Dantrolene and Esketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dantrolene commonly causes drowsiness, dizziness and weakness. With esketamine, sedation and impaired coordination may be increased.
What this interaction means in plain words
Dantrolene and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Esketamine belongs to Central Nervous System.
Why it happens
Additive CNS depression; dantrolene also causes skeletal muscle weakness.
What to do
Monitor sedation and motor function after esketamine dosing. Counsel the patient to avoid hazardous activities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Esketamine?
MediHelp rates the interaction as moderate. Dantrolene and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dantrolene commonly causes drowsiness, dizziness and weakness. With esketamine, sedation and impaired coordination may be increased.
How serious is the interaction between Dantrolene and Esketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and motor function after esketamine dosing. Counsel the patient to avoid hazardous activities.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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