Drug interactions
Dantrolene + Estazolam
Severity: Moderate
Dantrolene and Estazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estazolam is a hypnotic benzodiazepine that causes sedation and psychomotor impairment, and dantrolene adds drowsiness and muscle weakness. The combination can lead to excessive sedation, falls and next-day impairment.
What this interaction means in plain words
Dantrolene and Estazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A potentiation by estazolam and dantrolene sedation.
What to do
Use the lowest effective estazolam dose and monitor for oversedation, particularly in older adults. Advise against driving the day after dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Estazolam?
MediHelp rates the interaction as moderate. Dantrolene and Estazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Estazolam is a hypnotic benzodiazepine that causes sedation and psychomotor impairment, and dantrolene adds drowsiness and muscle weakness. The combination can lead to excessive sedation, falls and next-day impairment.
How serious is the interaction between Dantrolene and Estazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective estazolam dose and monitor for oversedation, particularly in older adults. Advise against driving the day after dosing.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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