Drug interactions
Dantrolene + Ethanol
Severity: Moderate
Dantrolene and Ethanol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Alcohol depresses the central nervous system, and dantrolene commonly causes drowsiness and dizziness. Drinking alcohol during dantrolene therapy may intensify sedation and impair coordination, and both can be hepatotoxic.
What this interaction means in plain words
Dantrolene and Ethanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with possible additive hepatic stress.
What to do
Advise patients to avoid alcohol during dantrolene treatment. Monitor liver function as part of routine dantrolene surveillance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Ethanol?
MediHelp rates the interaction as moderate. Dantrolene and Ethanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Alcohol depresses the central nervous system, and dantrolene commonly causes drowsiness and dizziness. Drinking alcohol during dantrolene therapy may intensify sedation and impair coordination, and both can be hepatotoxic.
How serious is the interaction between Dantrolene and Ethanol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid alcohol during dantrolene treatment. Monitor liver function as part of routine dantrolene surveillance.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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