Drug interactions
Dantrolene + Fentanyl
Severity: Moderate
Dantrolene and Fentanyl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dantrolene causes drowsiness, dizziness and weakness, which can add to the sedation and respiratory depression caused by fentanyl.
What this interaction means in plain words
Dantrolene and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Fentanyl belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for sedation and respiratory depression, particularly at initiation, and lower doses if excessive drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Fentanyl?
MediHelp rates the interaction as moderate. Dantrolene and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dantrolene causes drowsiness, dizziness and weakness, which can add to the sedation and respiratory depression caused by fentanyl.
How serious is the interaction between Dantrolene and Fentanyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression, particularly at initiation, and lower doses if excessive drowsiness occurs.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
Full monographs, dosing and an interaction checker in the MediHelp app
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