Drug interactions
Dantrolene + Fexinidazole
Severity: Moderate
Dantrolene and Fexinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dantrolene is metabolized in part by CYP3A4 and fexinidazole may inhibit this enzyme. Dantrolene exposure could rise, increasing drowsiness, weakness and the potential for hepatotoxicity. The interaction is predicted from the mechanism rather than well studied.
What this interaction means in plain words
Dantrolene and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by fexinidazole may reduce dantrolene metabolism.
What to do
Monitor for increased sedation, weakness and liver enzyme elevations during co-treatment. Consider dantrolene dose reduction if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Fexinidazole?
MediHelp rates the interaction as moderate. Dantrolene and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dantrolene is metabolized in part by CYP3A4 and fexinidazole may inhibit this enzyme. Dantrolene exposure could rise, increasing drowsiness, weakness and the potential for hepatotoxicity. The interaction is predicted from the mechanism rather than well studied.
How serious is the interaction between Dantrolene and Fexinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation, weakness and liver enzyme elevations during co-treatment. Consider dantrolene dose reduction if adverse effects appear.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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