Drug interactions
Dantrolene + Flurazepam
Severity: Moderate
Dantrolene and Flurazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurazepam is a long-acting hypnotic benzodiazepine whose active metabolite accumulates, and dantrolene adds drowsiness and weakness. The combination can produce marked sedation, falls and prolonged next-day impairment.
What this interaction means in plain words
Dantrolene and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A potentiation and dantrolene sedation.
What to do
Use the lowest effective flurazepam dose, especially in older adults, and monitor for oversedation and falls. Consider a shorter-acting hypnotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Flurazepam?
MediHelp rates the interaction as moderate. Dantrolene and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurazepam is a long-acting hypnotic benzodiazepine whose active metabolite accumulates, and dantrolene adds drowsiness and weakness. The combination can produce marked sedation, falls and prolonged next-day impairment.
How serious is the interaction between Dantrolene and Flurazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective flurazepam dose, especially in older adults, and monitor for oversedation and falls. Consider a shorter-acting hypnotic.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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