Drug interactions
Dantrolene + Ketamine
Severity: Moderate
Dantrolene and Ketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketamine produces dissociative anaesthesia and sedation, and dantrolene adds its own sedative effect. The combination may prolong or deepen central nervous system depression and delay recovery of alertness.
What this interaction means in plain words
Dantrolene and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Ketamine belongs to Central Nervous System.
Why it happens
Additive central nervous system depression.
What to do
Titrate ketamine to effect and monitor level of consciousness and respiratory status. Allow extra recovery time and supervision after procedures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Ketamine
Frequently asked questions
Can I take Dantrolene with Ketamine?
MediHelp rates the interaction as moderate. Dantrolene and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketamine produces dissociative anaesthesia and sedation, and dantrolene adds its own sedative effect. The combination may prolong or deepen central nervous system depression and delay recovery of alertness.
How serious is the interaction between Dantrolene and Ketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate ketamine to effect and monitor level of consciousness and respiratory status. Allow extra recovery time and supervision after procedures.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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