Drug interactions
Dantrolene + Levorphanol
Severity: Moderate
Dantrolene and Levorphanol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, and levorphanol can also depress breathing. Together they may cause stronger drowsiness, impaired alertness and respiratory depression than either drug alone.
What this interaction means in plain words
Dantrolene and Levorphanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from dantrolene's sedative effects and opioid agonism by levorphanol.
What to do
Start with low doses and titrate slowly, monitoring sedation level and respiratory rate. Warn patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Levorphanol?
MediHelp rates the interaction as moderate. Dantrolene and Levorphanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, and levorphanol can also depress breathing. Together they may cause stronger drowsiness, impaired alertness and respiratory depression than either drug alone.
How serious is the interaction between Dantrolene and Levorphanol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and titrate slowly, monitoring sedation level and respiratory rate. Warn patients to avoid driving and alcohol.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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