Drug interactions
Dantrolene + Lofepramine
Severity: Moderate
Dantrolene and Lofepramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dantrolene commonly causes drowsiness and lofepramine, a tricyclic antidepressant, can add sedative effects. The combination may impair alertness and psychomotor performance.
What this interaction means in plain words
Dantrolene and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects; lofepramine's antihistaminic and anticholinergic properties add to dantrolene's sedation.
What to do
Monitor for excessive sedation and counsel patients about driving and machinery. Reduce the dose of one agent if drowsiness becomes troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Lofepramine?
MediHelp rates the interaction as moderate. Dantrolene and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dantrolene commonly causes drowsiness and lofepramine, a tricyclic antidepressant, can add sedative effects. The combination may impair alertness and psychomotor performance.
How serious is the interaction between Dantrolene and Lofepramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and counsel patients about driving and machinery. Reduce the dose of one agent if drowsiness becomes troublesome.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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