Drug interactions
Dantrolene + Lormetazepam
Severity: Moderate
Dantrolene and Lormetazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dantrolene causes drowsiness and lormetazepam is a hypnotic benzodiazepine, so combined use can deepen sedation and impair next-day alertness and coordination. The risk of falls is increased.
What this interaction means in plain words
Dantrolene and Lormetazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through dantrolene's sedative effects and GABA-A potentiation by lormetazepam.
What to do
Use the lowest effective hypnotic dose and monitor for daytime sedation and unsteadiness. Counsel about driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Lormetazepam?
MediHelp rates the interaction as moderate. Dantrolene and Lormetazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dantrolene causes drowsiness and lormetazepam is a hypnotic benzodiazepine, so combined use can deepen sedation and impair next-day alertness and coordination. The risk of falls is increased.
How serious is the interaction between Dantrolene and Lormetazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective hypnotic dose and monitor for daytime sedation and unsteadiness. Counsel about driving and alcohol.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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