Drug interactions
Dantrolene + Loxapine inhaled
Severity: Moderate
Dantrolene and Loxapine inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled loxapine is sedating and can cause bronchospasm, and dantrolene adds to central depression. The combination may increase drowsiness and impair psychomotor function.
What this interaction means in plain words
Dantrolene and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from dantrolene and the antipsychotic loxapine (dopamine, histamine and other receptor blockade).
What to do
Monitor sedation level after each loxapine dose, and avoid driving or machinery after treatment. Reduce dantrolene dose if oversedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Loxapine inhaled?
MediHelp rates the interaction as moderate. Dantrolene and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inhaled loxapine is sedating and can cause bronchospasm, and dantrolene adds to central depression. The combination may increase drowsiness and impair psychomotor function.
How serious is the interaction between Dantrolene and Loxapine inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level after each loxapine dose, and avoid driving or machinery after treatment. Reduce dantrolene dose if oversedation occurs.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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