Drug interactions
Dantrolene + Marijuana
Severity: Moderate
Dantrolene and Marijuana: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis causes sedation, dizziness and impaired coordination, which may be added to the drowsiness and weakness caused by dantrolene. Combined use can impair driving and increase fall risk.
What this interaction means in plain words
Dantrolene and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects of cannabinoids and dantrolene.
What to do
Advise patients to avoid cannabis or limit use, and monitor for excess sedation and impaired function. Counsel on driving restrictions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Marijuana?
MediHelp rates the interaction as moderate. Dantrolene and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabis causes sedation, dizziness and impaired coordination, which may be added to the drowsiness and weakness caused by dantrolene. Combined use can impair driving and increase fall risk.
How serious is the interaction between Dantrolene and Marijuana?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid cannabis or limit use, and monitor for excess sedation and impaired function. Counsel on driving restrictions.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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