Drug interactions
Dantrolene + Metoclopramide intranasal
Severity: Moderate
Dantrolene and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide can cause sedation, drowsiness and extrapyramidal effects, and dantrolene also causes drowsiness and weakness. Combined use may increase CNS depression and impair psychomotor performance, although the interaction is poorly characterized.
What this interaction means in plain words
Dantrolene and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Probable additive CNS depressant effects; the mechanism is not well established.
What to do
Counsel the patient about additive drowsiness and avoid driving or hazardous tasks until response is known. Reduce metoclopramide dose or consider an alternative antiemetic if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Dantrolene and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide can cause sedation, drowsiness and extrapyramidal effects, and dantrolene also causes drowsiness and weakness. Combined use may increase CNS depression and impair psychomotor performance, although the interaction is poorly characterized.
How serious is the interaction between Dantrolene and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about additive drowsiness and avoid driving or hazardous tasks until response is known. Reduce metoclopramide dose or consider an alternative antiemetic if excessive sedation occurs.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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