Drug interactions
Dantrolene + Nafcillin
Severity: Moderate
Dantrolene and Nafcillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin is an inducer of CYP3A4 and may accelerate dantrolene metabolism, lowering its exposure. The clinical effect is poorly documented and likely modest.
What this interaction means in plain words
Dantrolene and Nafcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction by nafcillin increases hepatic clearance of dantrolene.
What to do
Monitor clinical response to dantrolene during nafcillin therapy and increase the dose if effect is reduced. Reassess after nafcillin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Nafcillin?
MediHelp rates the interaction as moderate. Dantrolene and Nafcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin is an inducer of CYP3A4 and may accelerate dantrolene metabolism, lowering its exposure. The clinical effect is poorly documented and likely modest.
How serious is the interaction between Dantrolene and Nafcillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to dantrolene during nafcillin therapy and increase the dose if effect is reduced. Reassess after nafcillin is stopped.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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