Drug interactions
Dantrolene + Olanzapine
Severity: Moderate
Dantrolene and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness and impaired alertness. Using them together may deepen sedation and increase the risk of falls or impaired performance.
What this interaction means in plain words
Dantrolene and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Olanzapine belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Monitor for excess sedation, particularly when starting or increasing either drug. Counsel patients on avoiding driving until tolerance is established.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Olanzapine
Frequently asked questions
Can I take Dantrolene with Olanzapine?
MediHelp rates the interaction as moderate. Dantrolene and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness and impaired alertness. Using them together may deepen sedation and increase the risk of falls or impaired performance.
How serious is the interaction between Dantrolene and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation, particularly when starting or increasing either drug. Counsel patients on avoiding driving until tolerance is established.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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