Drug interactions
Dantrolene + Olopatadine intranasal
Severity: Moderate
Dantrolene and Olopatadine intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intranasal olopatadine can cause somnolence, and dantrolene commonly causes drowsiness and dizziness. Together they may add to CNS depression and impair alertness and psychomotor performance.
What this interaction means in plain words
Dantrolene and Olopatadine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects of an antihistamine and a centrally acting muscle relaxant.
What to do
Warn the patient about additive drowsiness and advise against driving or operating machinery until tolerance is known. Consider a less sedating intranasal agent if impairment occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Olopatadine intranasal?
MediHelp rates the interaction as moderate. Dantrolene and Olopatadine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intranasal olopatadine can cause somnolence, and dantrolene commonly causes drowsiness and dizziness. Together they may add to CNS depression and impair alertness and psychomotor performance.
How serious is the interaction between Dantrolene and Olopatadine intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn the patient about additive drowsiness and advise against driving or operating machinery until tolerance is known. Consider a less sedating intranasal agent if impairment occurs.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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